A quick intro to block permutations and bootstraps for analyzing hierarchical data

Clustered data - such as multiple observations per individual, animal, or cell - are quite common in neuroscience research. Here I walk through an introduction to one approach to adjusting your analyses for clustering - block permutations and bootstrapping - that is widely applicable and makes very few assumptions.

Improving Genetic Prediction: Data cleaning & Meta-analysis

In my first post I showed how to build a simple model, using only genetic information, that predicts height, with 53% accuracy in an independent sample. In this post I’m going to improve that model, which will ultimately result in a model with 64% accuracy in an independent sample - an 11% improvement!

On Predicting Traits with Genetics

crowdAI is a VERY cool site that hosts machine learning competitions. They recently hosted a competition using data from openSNP, a website that lets anyone upload their genetic data, making it publicly available. About 3,500 people have uploaded some amount of their genetic data (many people just upload the mitochondrial portion), and 921 also reported their height. The crowdAI competition was, very simply, can you predict Height in a subset of these people, using the genetic data from everyone else to train a model?

And? I won!!! My best model predicts 53.45% of variance in Height, while the current next-best predicts 48.62%. But there’s a catch, even though it was a “machine learning”" competition, I didn’t actually use any ML…oops

This post is intended to give an explanation of why I participated and how I won, with the hope that others with more expertise in ML can benefit from my knowledge in genetics....